Purpose of review Butyrate
is physiologically produced by the microbial fermentation of dietary fibers and plays a plurifunctional role in intestinal cells. This review examines the recent findings regarding the role and mechanisms by which butyrate
regulates intestinal metabolism and discusses how these findings could improve the treatment of several gastrointestinal disorders.
Recent findings Butyrate
is more than a primary nutrient that provides energy to colonocytes and acts as a cellular mediator in those cells through several mechanisms. One remarkable property of butyrate
is its ability to inhibit histone deacetylases, which is associated with the direct effects of butyrate
and results in gene regulation, immune modulation, cancer
suppression, cell differentiation, intestinal barrier regulation, oxidative stress reduction, diarrhea control, visceral sensitivity and intestinal motility modulation. All of these actions make butyrate
an important factor for the maintenance of gut health.
From studies published over 30 years, there is no doubt of the important role that butyrate
plays in maintaining intestinal homeostasis. However, despite these effects, clinical studies are still required to validate the routine use of butyrate
in clinical practice and, specifically, in the treatment of intestinal diseases.