Role of zinc in the development and treatment of mood disordersCope, Elise C; Levenson, Cathy WCurrent Opinion in Clinical Nutrition & Metabolic Care: November 2010 - Volume 13 - Issue 6 - p 685–689 doi: 10.1097/MCO.0b013e32833df61a Micronutrients: Edited by Henry C. Lukaski and Gil Hardy Abstract Author Information Purpose of review The present review is a critical examination of the most recent published work on the role of zinc in the development and treatment of mood disorders. Recent findings Clinical studies and experimental work using animal models have both revealed a link between zinc status and neuropsychological disorders such as depression and anxiety. Not only has zinc deficiency been shown to induce depression-like and anxiety-like behaviors, supplementation has been used as a treatment for major depression. Zinc administration improves the efficacy of antidepressant drugs in depressed patients and may have a particular role to play in treatment-resistant patients. Recent investigations into the molecular mechanisms responsible for these observations suggest a role for zinc in the regulation of neurotransmitter systems, antioxidant mechanisms, neurotrophic factors, and neuronal precursor cells. Summary The data reviewed here not only indicate a role for zinc deficiency in the development of mood disorders, but also show that zinc may also be important in their treatment. Given the prevalence of zinc deficiency in human populations, this work has the potential to influence strategies to prevent and treat these disorders. Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA Correspondence to Cathy W. Levenson, PhD, Department of Biomedical Sciences, Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL 32306-4300, USA Tel: +1 850 644 4122; e-mail: email@example.com © 2010 Lippincott Williams & Wilkins, Inc.