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Regulation of muscle growth in neonates

Davis, Teresa A; Fiorotto, Marta L

Current Opinion in Clinical Nutrition and Metabolic Care: January 2009 - Volume 12 - Issue 1 - p 78–85
doi: 10.1097/MCO.0b013e32831cef9f
Protein, amino acid metabolism and therapy: Edited by Erich Roth and Elena Volpi
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Purpose of review This review reports recent findings on the multiple factors that regulate skeletal muscle growth in neonates.

Recent findings Skeletal muscle is the fastest growing protein mass in neonates. The high rate of neonatal muscle growth is due to accelerated rates of protein synthesis accompanied by the rapid accumulation of muscle nuclei. Feeding profoundly stimulates muscle protein synthesis in neonates and the response decreases with age. The feeding-induced stimulation of muscle protein synthesis is modulated by enhanced sensitivity to the postprandial rise in insulin and amino acids. Insulin and amino acid signaling components have been identified that are involved in the feeding-induced stimulation of protein synthesis in neonatal muscle. The enhanced activation of these signaling components in skeletal muscle of the neonate contributes to the high rate of muscle protein synthesis and rapid gain in muscle protein mass in neonates.

Summary Recent findings suggest that the immature muscle has a heightened capacity to activate signaling cascades that promote translation initiation in response to the postprandial rise in insulin and amino acids thereby enabling their efficient utilization for muscle growth. This capacity is further supported by enhanced satellite cell proliferation, but how these two processes are linked remains to be established.

USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA

Correspondence to Teresa A. Davis, PhD, USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030, USA Tel: +1 713 798 7169; fax: +1 713 798 7171; e-mail: tdavis@bcm.tmc.edu

© 2009 Lippincott Williams & Wilkins, Inc.