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Gut–brain axis

Romijn, Johannes A; Corssmit, Eleonora P; Havekes, Louis M; Pijl, Hanno

Current Opinion in Clinical Nutrition and Metabolic Care: July 2008 - Volume 11 - Issue 4 - p 518–521
doi: 10.1097/MCO.0b013e328302c9b0
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Purpose of review To summarize recent studies on the regulation and the functions of the gut–brain axis.

Recent findings Visual cues of food and food intake interact with the gut–brain axis at the level of the hypothalamus. However, the hypothalamic response to glucose intake is considerably altered in patients with type 2 diabetes mellitus, indicating involvement of the hypothalamus in the pathophysiology of this disease in humans. A large number of studies have documented the functions of gut peptides with respect to the regulation of satiety. Gut peptides are involved in the regulation of insulin secretion and sensitivity. Recent data indicate that peptide YY is a gut hormone that also modulates bone metabolism. Increasing evidence is obtained on the role of afferent gastrointestinal nerves, especially the vagal nerve, in the modulation of the functions of the gut–brain axis.

Summary The gut–brain axis is involved in a multitude of physiological processes including satiety, food intake, regulation of glucose and fat metabolism, insulin secretion and sensitivity and bone metabolism. It is likely, that more aspects of this system will be found the near future.

Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands

Correspondence to J.A. Romijn, MD, PhD, Department of Endocrinology and Metabolic Diseases, C4-R Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands Tel: +31 71 5263082; fax: +31 71 5248136; e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.