Citrulline and the gut : Current Opinion in Clinical Nutrition & Metabolic Care

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Nutrition and the gastrointestinal tract

Citrulline and the gut

Curis, Emmanuela; Crenn, Pascalb,c; Cynober, Lucb,d

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Current Opinion in Clinical Nutrition and Metabolic Care 10(5):p 620-626, September 2007. | DOI: 10.1097/MCO.0b013e32829fb38d


Purpose of review 

Citrulline, a nonprotein amino acid, is an important source of endogenous arginine. The gut is the main source of citrulline in humans. Hence, citrulline is a potential biomarker of short bowel function. Conversely, citrulline uptake by the gut is important for an oral supply of this amino acid as an alternative to arginine. This review discusses these two aspects of citrulline, as well as the recent developments in the understanding of its metabolism.

Recent findings 

Citrullinemia is such an efficient marker when the active mass of the bowel is affected that it can be used as a prognostic marker for parenteral nutrition weaning (if citrullinemia is >20 μmol/l) and as a factor for deciding between parenteral and enteral nutrition (as long as the pathology is considered). Citrullinemia should be used with care as a marker either of the intestinal absorption or following small bowel transplantation.


Citrulline is easily taken up by the gut, with a broad set of transporters that can remove it from the lumen in the enterocytes. This is confirmed by pharmacokinetic studies and the efficacy is so great that oral complementation with citrulline seems more efficient than complementation with arginine to provide arginine.

© 2007 Lippincott Williams & Wilkins, Inc.

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