CarbohydratesMetabolic effects of fructoseLê, Kim-Annea; Tappy, Luca,bAuthor Information aDepartment of Physiology, Faculty of Medicine, University of Lausanne, Lausanne, Switzerland bService of Endocrinology, Diabetes and Metabolism, University Hospital, Lausanne, Switzerland Correspondence to Prof. Luc Tappy, Département de Physiologie, University of Lausanne, 7 rue du Bugnon, 1005 Lausanne, Switzerland Tel: +41 21 692 55 41; fax: +41 21 692 55 95; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: July 2006 - Volume 9 - Issue 4 - p 469-475 doi: 10.1097/01.mco.0000232910.61612.4d Buy Metrics Abstract Purpose of review Fructose is consumed in significant amounts in Western diets. An increase in fructose consumption over the past 10–20 years has been linked with a rise in obesity and metabolic disorders. Fructose/sucrose produces deleterious metabolic effects in animal models. This raises concern regarding the short-term and long-term effects of fructose and its risk in humans. Recent findings In rodents, fructose stimulates lipogenesis and leads to hepatic and extrahepatic insulin resistance, dyslipidaemia and high blood pressure. Insulin resistance appears to be related to ectopic lipid deposition. In humans, short-term fructose feeding increases de-novo lipogenesis and blood triglycerides and causes hepatic insulin resistance. There is presently no evidence for fructose-induced muscle insulin resistance in humans. The cellular mechanisms underlying the metabolic effects of fructose involve production of reactive oxygen species, activation of cellular stress pathways and possibly an increase in uric acid synthesis. Summary Consuming large amounts of fructose can lead to the development of a complete metabolic syndrome in rodents. In humans, fructose consumed in moderate to high quantities in the diet increases plasma triglycerides and alters hepatic glucose homeostasis, but does not appear to cause muscle insulin resistance or high blood pressure in the short term. Further human studies are required to delineate the effects of fructose in humans. © 2006 Lippincott Williams & Wilkins, Inc.