CarbohydratesBrain glucose sensing mechanism and glucose homeostasisPénicaud, Luc; Leloup, Corinne; Lorsignol, Anne; Alquier, Thierry; Guillod, Elise Author Information Unité Mixte de Recherche 5018 Centre National de la Recherche Scientifique, University Paul Sabatier, Toulouse cedex, France. Tel: +33 5 62 17 08 91; fax: +33 5 62 17 09 05; e-mail: [email protected] Abbreviations Glut2: glucose transporter 2 KATP channel: ATP sensitive K+ channel SUR: sulfonylurea receptor Current Opinion in Clinical Nutrition and Metabolic Care: September 2002 - Volume 5 - Issue 5 - p 539-543 Buy Abstract Purpose of review Glucose homeostasis must be finely regulated. Changes in glucose levels elicit a complex neuroendocrine response that prevents or rapidly corrects hyper- or hypoglycemia. It is well established that different parts of the brain, particularly the hypothalamus and the brain stem, are important centres involved in the monitoring of glucose status and the regulation of feeding. The pioneering work of Mayer, including his proposal of the glucostatic theory, has recently received experimental support from the molecular, electro-physiological and physiological fields. Recent findings Making the analogy with the β cell of the islet of Langerhans, it has been proposed that glucose sensing could be assured in some cells of the brain by proteins such as glucose transporter 2, glucokinase and the ATP-dependent potassium channel. Furthermore, some pathological conditions such as diabetes and obesity have been shown to alter this glucose sensing system. Summary These findings could lead to a better understanding of metabolic disorders, with hypoglycemia possibly being the most deleterious. © 2002 Lippincott Williams & Wilkins, Inc.