Review ArticleOestrogen and sex influence on muscle damage and inflammation: evidence from animal modelsTiidus, Peter M.Author Information Correspondence to Professor Peter M. Tiidus, PhD, Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, Ontario, Canada N2L 3C5. Tel: +1 519 884 0710 (ext. 4157); fax: +1 519 884 8829; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: November 2001 - Volume 4 - Issue 6 - p 509-513 Buy Abstract Recent evidence suggests that oestrogen and sex may influence the degree of disruption and post-damage inflammatory response seen in skeletal muscle. Evidence primarily from animal models suggests that oestrogen may be able to attenuate muscle disruption and attenuate or delay muscle leukocyte infiltration after contraction-induced and ischaemia-reperfusion-induced damage. Several potential mechanisms for this effect are discussed, along with the potential for oestrogen to influence the ultimate rate of skeletal muscle recovery from damage. © 2001 Lippincott Williams & Wilkins, Inc.