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Regulation of mammalian iron homeostasis

Schneider, Brian D.; Leibold, Elizabeth A.

Current Opinion in Clinical Nutrition and Metabolic Care: July 2000 - Volume 3 - Issue 4 - p 267-273
Review Article
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Iron homeostasis is regulated with respect to uptake, storage and utilization. Newer work is presented that defines proteins responsible for iron transport, sequestration and sensing, and that addresses their regulation at the cellular and organismal levels by ambient iron concentrations, demand for erythropoiesis, body iron burden, and redox stimuli.

Departments of Internal Medicine and Oncological Sciences and Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, USA

Correspondence to Elizabeth A. Leibold, Eccles Program in Human Molecular Biology and Genetics, University of Utah, 15 N. 2030 E. Salt Lake City, UT 84112, USA. Tel: +1 801 585 5002; Fax: +1 801 585 3501; e-mail: betty.leibold@hci.utah.edu

© 2000 Lippincott Williams & Wilkins, Inc.