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Cystic fibrosis: nutritional status and micronutrients

Winklhofer-Roob, Brigitte M.

Current Opinion in Clinical Nutrition and Metabolic Care: July 2000 - Volume 3 - Issue 4 - p 293-297
Review Article

Recent studies have focused on the current dietary intake of cystic fibrosis patients, the impact of nutritional support on both the nutritional status and clinical outcome variables, and the effects on the nutritional status of antibiotic therapy and surgical treatment of meconium ileus. In addition to weight and height, skinfold measurements, bioelectrical impedance analysis and dual energy X-ray absorptiometry have been employed for the determination of nutritional status. A proton pump inhibitor has been used successfully along with pancreatic enzymes for the improvement of fat absorption. Attention has been paid to resting energy expenditure during pulmonary exacerbations, to vitamin K function in bone mineralization and to risk factors for low bone mineral density in cystic fibrosis. The relationships between glutathione and nutritional status have been studied, along with possible interactions with albumin, a potent antioxidant. Finally, a beneficial effect of docosahexaenoic acid on cystic fibrosis pathology has been suggested, but this requires further critical evaluation.

Institute of Molecular Biology, Biochemistry and Microbiology, Karl-Franzens University, Graz, Austria

Correspondence to Brigitte M. Winklhofer-Roob, Institute of Molecular Biology, Biochemistry and Microbiology, Karl-Franzens University, Schubertstrasse 1, A-8010 Graz, Austria. Tel: +43 316 380 5490; fax: +43 316 380 9857; e-mail:

© 2000 Lippincott Williams & Wilkins, Inc.