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Insulin resistance: a marker of surgical stress

Thorell, Andersa; Nygren, Jonasb; Ljungqvist, Ollea

Current Opinion in Clinical Nutrition and Metabolic Care: January 1999 - Volume 2 - Issue 1 - p 69-78
Review Article

Elective surgery causes a marked, transient reduction in insulin sensitivity. The degree of the reduction is related to the magnitude of the operation. The type and duration of surgery performed, perioperative blood loss, and also the degree of postoperative insulin resistance have significant influences on the length of hospital stay. A novel approach to minimize insulin resistance after surgery is being presented and suggests that simply pretreating the elective surgical patient with sufficient amounts of carbohydrates instead of fasting can significantly reduce postoperative insulin resistance. It is not clear which mediators are the most important for the development of insulin resistance after surgery. Nevertheless, marked insulin resistance can develop after elective surgery without concomitant elevations in cortisol, catecholamines or glucagon. The main sites for insulin resistance seem to be extrahepatic tissues, probably skeletal muscle, where preliminary data suggest that the glucose transporting system is involved.

aDepartment of Surgery, Huddinge University Hospital, Huddinge, Sweden; and bKarolinska Hospital, Stockholm, Sweden

Correspondence to Olle Ljungqvist MD, PhD, Department of Surgery, Karolinska Institute, Huddinge University Hospital, S 141 86 Huddinge, Sweden

© 1999 Lippincott Williams & Wilkins, Inc.