REVIEWMitral valve surgery after failed transcatheter edge-to-edge repair: a review and word of cautionEl-Eshmawi, Ahmeda; Costa, Ana Claudiaa; Boateng, Percya; Pandis, Dimosthenisa; Israel, Yonatanb; Adams, David H.a; Tang, Gilbert H.L.a Author Information aDepartment of Cardiovascular Surgery, Mount Sinai Hospita bIcahn School of Medicine at Mount Sinai, New York, New York, USA Correspondence to Ahmed El-Eshmawi, MD, Department of Cardiovascular Surgery, Mount Sinai Hospital, 1190 Fifth Avenue, Box 1028, New York, NY 10029, USA. Tel: +1 212 659 6800; fax: +1 212 659 6818; e-mail: [email protected] Current Opinion in Cardiology: September 29, 2022 - Volume - Issue - 10.1097/HCO.0000000000000991 doi: 10.1097/HCO.0000000000000991 Buy PAP Metrics Abstract Purpose of review As transcatheter edge-to-edge mitral valve repair (TEER) evolves and indications broaden to include younger and lower surgical risk patients, it is essential to understand TEER failure trends and potential impact on subsequent mitral valve surgery, especially when pertaining to feasibility of durable valve reconstruction as opposed to de-novo repair. Recent findings Results of the two largest series analysing mitral valve surgery following TEER have demonstrated remarkably low repairability rates with consequent need for valve replacement. Post TEER surgery was associated with high early and late mortalities, likely as a reflection of patient baseline characteristics and acuity of surgery. Presence and correction of concomitant cardiac pathologies were a frequent finding. Centre and surgeon volumes were important factors in optimizing the likelihood of salvage repair and reducing perioperative risks. Summary Surgical mitral valve repair in reference centres remain the gold standard and the most durable treatment for degenerative mitral disease with excellent perioperative safety outcomes. Given the high likelihood of needing high-risk mitral valve replacement when TEER fails, consideration for potentially less durable transcatheter alternatives should be taken with caution in younger or lower surgical risk patients. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.