REVIEWHypertension and cognitive function: a review of life-course factors and disparitiesDe Anda-Duran, Ileanaa; Woltz, Sara G.a; Bell, Caryn N.a; Bazzano, Lydia A.a,b,c Author Information aTulane University School of Public Health and Tropical Medicine bTulane University School of Medicine cOchsner Clinic Foundation, New Orleans, Los Angeles, USA Correspondence to Lydia A. Bazzano, MD, PhD, 1440 Canal St., Ste. 2034, #8318, New Orleans, LA 70112, USA. Tel: +504 988 7323; e-mail: [email protected] Current Opinion in Cardiology ():10.1097/HCO.0000000000000975, June 28, 2022. | DOI: 10.1097/HCO.0000000000000975 Buy PAP Metrics Abstract Purpose of review Dementia is a life-course condition with modifiable risk factors from cardiovascular (CV) origin, that disproportionally affects some race/ethnic groups and underserved communities in the USA. Hypertension (HTN) is the most common preventable and treatable condition that increases the risk for dementia and exacerbates dementia pathology. Epidemiological studies beginning in midlife provide strong evidence for this association. This study provides an overview of the differences in the associations across the lifespan, and the role of social determinants of health (SDoH). Recent findings Clinical trials support HTN management in midlife as an avenue to lower the risk for late-life cognitive decline. However, the association between HTN and cognition differs over the life course SDoH including higher education modify the association between HTN and cognition which may differ by race and ethnicity. The role of blood pressure (BP) variability, interactions among CV risk factors, and cognitive assessment modalities may provide information to better understand the relationship between HTN and cognition. Summary Adopting a life-course approach that considers SDoH, may help develop tailored interventions to manage HTN and prevent dementia syndromes. Where clinical trials to assess BP management from childhood to late-life are not feasible, observational studies remain the best available evidence. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.