ISCHEMIC HEART DISEASE: Edited by Peter H. StoneFrequency and outcomes of periprocedural myocardial infarction in patients with chronic coronary syndromes undergoing percutaneous coronary interventionUeki, Yasushi; Räber, Lorenz Author Information Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland Correspondence to Prof. Lorenz Räber, MD, PhD, Department of Cardiology, Bern University Hospital Inselspital, University of Bern, 3010 Bern, Switzerland. Tel: +41 31 632 09 29; fax: +41 31 632 11 31; e-mail: [email protected] Current Opinion in Cardiology: November 2022 - Volume 37 - Issue 6 - p 488-494 doi: 10.1097/HCO.0000000000000995 Buy Metrics Abstract Purpose of review Various definitions of periprocedural myocardial infarction (MI) have been proposed by academic groups and professional societies differing in terms of biomarker thresholds and ancillary criteria for myocardial ischemia. The incidence and clinical significance of periprocedural MI substantially varies according to the definitions applied. In this review, we summarize available clinical data on the frequency and outcomes of periprocedural MI according to various MI definitions in patients undergoing percutaneous coronary intervention (PCI). Recent findings Numerous clinical studies and meta-analyses have investigated the incidence and prognostic relevance of periprocedural MI following PCI. The incidence of periprocedural MI was higher when defined by universal definition of myocardial infarction (UDMI), which applies a lower biomarker threshold with broader ancillary criteria compared with the Society for Cardiovascular Angiography and Intervention (SCAI) and academic research consortium (ARC)-2. The prognostic impact of periprocedural MI defined by SCAI and ARC-2 on mortality was consistently greater compared with the UDMI definition. Summary Among chronic coronary syndrome patients undergoing PCI, the frequency and prognostic value of periprocedural MI varies considerably based on definitions. Periprocedural MI defined by the ARC-2 and SCAI occurred 3–6 times less frequently and were prognostically more relevant as compared with the UDMI. Clinically relevant definitions should be used in daily practice and clinical trials. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.