CARDIAC FAILURE: Edited by Rebecca Cogswell and Gene KimArrhythmias and sudden cardiac death in post-cardiac transplant patientsEskander, Michael A.; Adler, Eric; Hoffmayer, Kurt S.Author Information Department of Electrophysiology, Sulpizio Cardiovascular Center, University of California, San Diego Health System, San Diego, California, USA Correspondence to Kurt S. Hoffmayer, PharmD, MD, UC San Diego Health, Department of Cardiac Electrophysiology, 9453 Medical Center Dr, MC 7411, La Jolla, CA 92037, USA. Tel: +1 858 246 2972; fax: +1 858 246 2958; e-mail: email@example.com Current Opinion in Cardiology: May 2020 - Volume 35 - Issue 3 - p 308-311 doi: 10.1097/HCO.0000000000000731 Buy Metrics Abstract Purpose of review Orthotopic heart transplantation (OHT) significantly improves morbidity and mortality in patients with end-stage heart disease. Despite advances in surgical technique, immunosuppressive therapies, and patient monitoring, long-term risk of arrhythmias and sudden cardiac death (SCD) in the denervated heart remains unchanged. Recent findings SCD is responsible for approximately 10% of all posttransplant deaths with a pooled incidence rate of 1.30 per 100 person years and is strongly associated with cardiac allograft vasculopathy (CAV). Risk factors for SCD and CAV include higher donor age, younger recipient age, and reduced left ventricular ejection fraction. Little is known about the time course between CAV and SCD. Although some registry data establish ventricular fibrillation as a documented terminal rhythm, the arrhythmia may not be the mechanism of SCD. Summary In this review, we identify risk factors and general independent predictors of arrhythmia and SCD and discuss the utility of implantable cardiac defibrillators in post-cardiac transplant patients. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.