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Vitamin D supplements and prevention of cardiovascular disease

Orkaby, Ariela R.a,b,c; Djousse, Lucb,c; Manson, JoAnn E.d,e

doi: 10.1097/HCO.0000000000000675
ISCHEMIC HEART DISEASE: Edited by Peter H. Stone

Purpose of review The role of vitamin D supplementation for prevention of cardiovascular disease (CVD) outcomes has been rigorously studied only recently. This review briefly summarizes results from recent randomized controlled trials in the context of prior laboratory and epidemiologic data.

Recent findings Randomized trials of vitamin D that included CVD outcomes, as well as two recently published large population-based trials that prespecified CVD as a primary endpoint (The Vitamin D Assessmentand The VITamin D and OmegA-3 TriaL), indicate that vitamin D supplementation does not decrease CVD incidence, when compared with placebo.

Summary Evidence to date suggests that vitamin D supplementation in the general community does not reduce the risk of major cardiovascular events. Other trials are ongoing and future studies will explore additional CVD outcomes such as heart failure and assess high-risk populations such as those with chronic kidney disease.

aNew England GRECC (Geriatric Research, Education, and Clinical Center), VA Boston Healthcare System

bDivision of Aging, Brigham and Women's Hospital, Harvard Medical School

cMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System

dDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School

eDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

Correspondence to JoAnn E. Manson, MD, DrPH, Department of Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, 3rd Fl, Boston, MA 02215, USA. Tel: +1 617 278 0871; fax: +1 617 731 3843; e-mail:

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