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Noncoding RNAs in cardiovascular diseases

Gurha, Priyatansh

Current Opinion in Cardiology: May 2019 - Volume 34 - Issue 3 - p 241–245
doi: 10.1097/HCO.0000000000000615
MOLECULAR GENETICS: Edited by Ali J. Marian
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Purpose of review Human genome is pervasively transcribed, producing coding and noncoding RNAs. Recent studies have revealed the roles of a class of noncoding RNAs, the long noncoding RNAs (lncRNAs), in heart failure and other cardiovascular diseases. This review provides a brief summary of recent findings on lncRNA function.

Recent findings Recent studies have documented the roles of lncRNAs in cardiac regeneration, conduction, hypertrophy/dysfunction, and endothelial function. LncRNAs perform these functions through acting as competing RNA (by binding and sequestering MicroRNAs) or acting as guides to protein targeting. A few lncRNAs also encode small peptides (e.g., Dwarf Open Reading Frame RNA) and in the context of heart regulate cardiac calcium homeostasis.

Summary Noncoding RNA provides a versatile mechanism of gene regulation and thereby present as novel targets for intervention in various cardiovascular disease. Future studies aimed at defining the context-dependent lncRNA mechanisms will be required to advance our understanding and relish the goal of RNA therapeutics.

Center for Cardiovascular Genetics, Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Texas, USA

Correspondence to Priyatansh Gurha, PhD, Center for Cardiovascular Genetics, Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, TX 77030, USA. Tel: +1 713-500-2335; e-mail: Priyatansh.gurha@uth.tmc.edu

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