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The long noncoding RNA landscape in cardiovascular disease: a brief update

Salamon, Irenea,b; Saccani Jotti, Gloriac; Condorelli, Gianluigia,b,d

Current Opinion in Cardiology: May 2018 - Volume 33 - Issue 3 - p 282–289
doi: 10.1097/HCO.0000000000000507
MOLECULAR GENETICS: Edited by Ali J. Marian

Purpose of review In this review, we summarize new knowledge on long noncoding RNAs (lncRNAs) linked to cardiovascular disease, in particular to heart failure.

Recent findings LncRNAs are dysregulated in specific developmental and pathological conditions and regulate critical responses to stress. LncRNAs are being recognized as molecules regulating myocardial remodeling during disease, participating for instance in the regulation of cardiomyocyte hypertrophy and function and fibroblast proliferation.

Summary LncRNAs add a new layer of complexity to the regulation of the biological processes underlying normal cardiac development and myocardial remodeling during disease; they may represent targets for novel therapeutic strategies for cardiovascular diseases.

aDepartment of Cardiovascular Medicine, Humanitas Research Hospital

bHumanitas University, Milan

cDepartment of Medicine and Surgery, Biotechnological and Translational Sciences, University of Parma, Parma

dInstitute of Genetic and Biomedical Research, National Research Council of Italy, Milan, Italy

Correspondence to Gianluigi Condorelli, MD, PhD, Department of Cardiovascular Medicine, Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy. Tel: +39 02 82244635; fax: +39 02 82245404; e-mail: gianluigi.condorelli@hunimed.eu

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