In this review, we summarize new knowledge on long noncoding RNAs (lncRNAs) linked to cardiovascular disease, in particular to heart failure.
LncRNAs are dysregulated in specific developmental and pathological conditions and regulate critical responses to stress. LncRNAs are being recognized as molecules regulating myocardial remodeling during disease, participating for instance in the regulation of cardiomyocyte hypertrophy and function and fibroblast proliferation.
LncRNAs add a new layer of complexity to the regulation of the biological processes underlying normal cardiac development and myocardial remodeling during disease; they may represent targets for novel therapeutic strategies for cardiovascular diseases.
aDepartment of Cardiovascular Medicine, Humanitas Research Hospital
bHumanitas University, Milan
cDepartment of Medicine and Surgery, Biotechnological and Translational Sciences, University of Parma, Parma
dInstitute of Genetic and Biomedical Research, National Research Council of Italy, Milan, Italy
Correspondence to Gianluigi Condorelli, MD, PhD, Department of Cardiovascular Medicine, Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy. Tel: +39 02 82244635; fax: +39 02 82245404; e-mail: firstname.lastname@example.org