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Behçet's disease and risk of vascular events

Balta, Sevket; Balta, Ilknur; Ozturk, Cengiz; Celik, Turgay; Iyisoy, Atila

Current Opinion in Cardiology: July 2016 - Volume 31 - Issue 4 - p 451–457
doi: 10.1097/HCO.0000000000000281
LIPIDS AND EMERGING RISK FACTORS: Edited by Dimitri P. Mikhailidis and Anthony S. Wierzbicki

Purpose of review We discuss the relationship between several factors and the risk of vascular events in patients with Behçet's disease.

Recent findings Behçet's disease, a systemic, chronic relapsing vasculitis, is mainly seen in the Mediterranean area and is typically characterized by recurrent oro-genital ulcers, ocular inflammation, and skin manifestations, including articular, vascular, gastroenteric, and neurological involvement. It is a chronic inflammatory disease with relapses and remissions. The prognosis varies. Behçet's disease can cause venous or arterial lesions. Vascular involvement contributes to the mortality and morbidity associated with Behçet's disease.

Summary The cause of thrombosis or vascular events in Behçet's disease remains incompletely understood; several factors have been studied with conflicting results. Vasculitis is considered to underlie several clinical manifestations of Behçet's disease.

aDepartment of Cardiology, Gulhane Medical Academy

bDepartment of Dermatology, Ankara Training and Research Hospital, Ankara, Turkey

Correspondence to Sevket Balta, MD, Department of Cardiology, Gulhane School of Medicine, Tevfik Saglam St, 06018 Etlik-Ankara, Turkey. Tel: +90 312 3044281; fax: +90 312 3044250; e-mail:,

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