Diseases of the aorta, pulmonary and peripheral vessels: Edited by Alan BravermanBiomarker-assisted diagnosis of acute aortic dissection: how far we have come and what to expectSuzuki, Torua; Distante, Alessandrob; Eagle, KimcAuthor Information aThe University of Tokyo, Tokyo, Japan bIstituto Scientifico Biomedico Euro Mediterraneo, Brindisi, Institute of Clinical Physiology, National Research Council, Lecce, and University Medical School, Pisa, Italy cUniversity of Michigan, Ann Arbor, Michigan, USA Correspondence to Dr Toru Suzuki, MD, Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan Tel: +81 3 5800 9846; fax: +81 3 5800 9847; e-mail: [email protected] Current Opinion in Cardiology: November 2010 - Volume 25 - Issue 6 - p 541-545 doi: 10.1097/HCO.0b013e32833e6e13 Buy Metrics Abstract Purpose of review Acute aortic dissection is a disease that is often a challenge to diagnose. Early and immediate diagnosis is important for initiation of treatment and improved survival. Despite recent advances in imaging methods to diagnose the disease, biochemical methods are not available. Recent findings Biomarkers that might be useful for the biochemical detection of acute aortic dissection have been recently described, such as assays for the circulating proteins, smooth muscle myosin heavy chain, creatine kinase BB-isozyme, calponin (smooth muscle troponin) and elastin. C-reactive protein and D-dimer have also been shown to be useful. Summary Biomarker-assisted diagnosis of acute aortic dissection would be helpful in detecting this acute catastrophic aortic disease, which still remains a challenge to diagnose. Although recent progress in development of biomarkers has been made, there is no widely accepted strategy. Available biomarkers such as D-dimer may play an assistive role in the meantime. © 2010 Lippincott Williams & Wilkins, Inc.