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Pathophysiology of abdominal aortic aneurysm relevant to improvements in patients' management

Golledge, Jonathana; Norman, Paul Eb

doi: 10.1097/HCO.0b013e328330c2d3
Diseases of the aorta, pulmonary and peripheral vessels: Edited by Alan C. Braverman

Purpose of review Abdominal aortic aneurysm (AAA) is being diagnosed more frequently in older patients due to the increased use of abdominal imaging and the rising average age of western populations. Currently the management of this condition has two important deficiencies: inadequate methods to identify AAAs at risk of progression and rupture and the current lack of effective nonsurgical therapies. In this review recent developments in identifying new diagnostic, prognostic and therapeutic strategies for AAA are discussed.

Recent findings There are growing number of animal and human association studies which have identified markers and strategies of potential value in improving identification, monitoring and treatment of AAA.

Summary Selective large prospective imaging, biomarker and intervention studies are now required to clearly demonstrate the value of new management pathways for AAA.

aThe Vascular Biology Unit, School of Medicine, James Cook University, Townsville, Australia

bSchool of Surgery, University of Western Australia, Fremantle Hospital, Fremantle, Australia

Correspondence to Professor Jonathan Golledge, Director, The Vascular Biology Unit, Department of Surgery, School of Medicine, James Cook University Townsville, QLD 4811, Australia Tel: +61 7 4796 1417; fax: +61 7 4796 1401; e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.