Heart failure: Edited by Haissam HaddadUtility of B-natriuretic peptide in the evaluation of left ventricular diastolic function and diastolic heart failureParekh, Niraj; Maisel, Alan S Author Information Department of Cardiology, Veterans Affairs Hospital, University of California at San Diego, San Diego, California, USA Correspondence to Alan Maisel, MD, Cardiology Section, VA San Diego Healthcare System, 3350 La Jolla Villa Drive, Mail Code: 9111A, San Diego, CA 92161, USA Tel: +1 858 552 8585, ext 7344; fax: +1 858 642 3617; e-mail: [email protected] Current Opinion in Cardiology: March 2009 - Volume 24 - Issue 2 - p 155-160 doi: 10.1097/HCO.0b013e328320d82a Buy Metrics Abstract Purpose of review Heart failure with preserved ejection fraction or diastolic heart failure is an increasingly prevalent disease process today. Natriuretic peptides have been shown to provide diagnostic and prognostic utility in patients with systolic heart failure. Here we review current publications exploring the relationship between B-natriuretic peptide (BNP) and diastolic dysfunction. Recent findings Investigators have found significant correlations between echocardiographic parameters for diastolic dysfunction and serum BNP levels in diagnosing diastolic heart failure. This relationship is linear with respect to severity of left ventricular dysfunction. Newer echocardiographic modalities like tissue Doppler imaging provide measures of elevated left ventricular filling pressures, which are associated with higher plasma BNP levels. Admission and predischarge BNP levels in patients with decompensated diastolic heart failure have been prognostic with respect to in-hospital mortality, short-term mortality, and hospital readmission. Summary Review of current literature shows that BNP can be useful in providing diagnostic and prognostic data in patients with symptomatic and asymptomatic diastolic dysfunction. These data, combined with other values such as echocardiographic indices and cardiovascular risk factors, can augment the sensitivity and specificity of BNP. © 2009 Lippincott Williams & Wilkins, Inc.