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Fibrosis and hypertensive heart disease

Weber, Karl T. MD

Current Opinion in Cardiology: July 2000 - Volume 15 - Issue 4 - p 264-272
Hypertension

The normal myocardium is composed of a variety of cells: cardiac myocytes and noncardiomyocytes, which include endothelial and vascular smooth muscle cells and fibroblasts. Hypertensive heart disease involves a structural remodeling of muscular and nonmuscular compartments. It is not the quantity but rather the quality of myocardium that accounts for pathologic hypertrophy and predisposes to ventricular dysfunction and arrhythmias, which, in turn, confer increased risk of adverse cardiovascular events. Herein, factors regulating growth of these compartments are reviewed and in particular signals involved in promoting adverse remodeling of intramyocardial coronary arteries and arterioles by fibrous tissue.

Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA

Correspondence to Karl T. Weber, MD, Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Room 353 Dobbs Research Institute, 951 Court Avenue, Memphis, Tennessee, 38163, USA; e-mail: ktweber@utmem.edu

© 2000 Lippincott Williams & Wilkins, Inc.