Hypertension: PDF OnlyHypertensive heart disease and the diabetic patientGrossman, Ehud MD; Rosenthal, Talma MDAuthor Information Chaim Sheba Medical Center, Tel-Hashomer, Israel Current Opinion in Cardiology 1995, 10:458–465 Current Opinion in CARDIOLOGY: September 1995 - Volume 10 - Issue 5 - p 458-465 Buy Abstract Patients with diabetes mellitus are particularly vulnerable to cardiovascular disease. Although structural and functional myocardial complications are present in patients with diabetes alone, they are particularly severe in patients with both diabetes and hypertension. Considerable evidence-both in experimental animal models and in humans-points to hypertension as of critical importance in the pathogenesis of severe diabetic heart disease. In diabetic hypertensive cardiomyopathy, coronary artery disease as well as structural and functional abnormalities are more pronounced than would be expected from either process alone. The myocardial damage is attributed mainly to hypertension, whereas the myocellular dysfunction is attributed mainly to diabetes. Together, the consequences to the myocardium are devastating. Strict control of the hypertension and diabetes may have an ameliorative effect on the subsequent development of diabetic heart disease. Copyright © 1995 Wolters Kluwer Health, Inc. All rights reserved.