Stratification of neuropathic pain patients: the road to mechanism-based therapy? : Current Opinion in Anesthesiology

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PAIN MEDICINE: Edited by Esther Pogatzki-Zahn

Stratification of neuropathic pain patients

the road to mechanism-based therapy?

Forstenpointner, Julia; Rehm, Stefanie; Gierthmühlen, Janne; Baron, Ralf

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Current Opinion in Anaesthesiology 31(5):p 562-568, October 2018. | DOI: 10.1097/ACO.0000000000000642


Purpose of review 

It has been demonstrated that within one pain entity, patients may report highly heterogenic sensory signs and symptoms. Although mechanism might differ fundamentally between those patients, yet the treatment recommendations are uniform throughout all phenotypes. Therefore, the introduction of new stratification tools could pave the way to an individualized pain treatment.

Recent findings 

In the past, retrospective stratifications of patients successfully identified responders to certain pharmacological treatments. This indicated predictive validity and reliability of this classification tool in those patient subgroups. Further on, these observations have been confirmed in prospective studies.


This review focusses on recent achievements in neuropathic pain and suggests a promising implementation of an individualized pharmacological therapy in the future.

Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.

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