GERIATRIC ANESTHESIA: Edited by Rainer KiefmannPharmacodynamics and pharmacokinetics in older adultsThürmann, Petra A.Author Information Helios University Hospital Wuppertal, Chair of Clinical Pharmacology, University Witten/Herdecke, Wuppertal, Germany Correspondence to Petra A. Thürmann, Helios University Hospital Wuppertal, Chair of Clinical Pharmacology, University Witten/Herdecke, Heusnerstr. 40, D-42283 Wuppertal, Germany. Tel: +49 202 896 1851; fax: +49 202 896 1852; e-mail: [email protected] Current Opinion in Anaesthesiology: February 2020 - Volume 33 - Issue 1 - p 109-113 doi: 10.1097/ACO.0000000000000814 Buy Metrics Abstract Purpose of review With the growing of the aging population, increased and new methods of anesthesia and surgery allow for surgery and other interventions in older adults. Pharmacokinetics and pharmacodynamics of drugs in older adults differ from those in younger and middle-aged adults. However, the geriatric population is frequently neglected in the context of clinical trials. The present review focuses on the consequences of multimorbidity and pharmacokinetic and pharmacodynamic alterations and their implications on anesthesia. Recent findings Physiologically based pharmacokinetic and pharmacodynamic modeling may serve as an option to better understand the influence of age on drugs used for anesthesia. However, difficulties to adequately characterize geriatric patients are described. Summary Further research of drug effects in the aging population may include physiologically based pharmacokinetic and pharmacodynamic complex models and randomized controlled trials with thoroughly conducted geriatric assessments. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.