REGIONAL ANESTHESIA: Edited by Stephan C. KettnerRegional anesthesia in pain managementCuratolo, Michele Author Information Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, USA Correspondence to Michele Curatolo, MD, PhD, Department of Anesthesiology and Pain Medicine, University of Washington, 1959 NE Pacific Street, Box 356540, Seattle, WA 98195-6540, USA. Tel: +1 206 543 2673; e-mail: [email protected] Current Opinion in Anaesthesiology: October 2016 - Volume 29 - Issue 5 - p 614-619 doi: 10.1097/ACO.0000000000000353 Buy Metrics Abstract Purpose of review The study focuses on neural blocks with local anesthetics in postoperative and chronic pain. It is prompted by the recent publication of several systematic reviews and guidelines. Recent findings For postoperative pain, the current evidence supports infusions of local anesthetics at the surgical site, continuous peripheral nerve blocks, and neuraxial analgesia for major thoracic and abdominal procedures. Ultrasound guidance can improve the performance of the blocks and different patient outcomes, although the incidence of peripheral nerve damage is not decreased. For chronic pain, the best available evidence is on nerve blocks for the diagnosis of facet joint pain. Further research is needed to validate diagnostic nerve blocks for other indications. Therapeutic blocks with only local anesthetics (greater occipital nerve and sphenopalatine ganglion) are effective in headache. A possible mechanism is modulation of central nociceptive pathways. Therapeutic nerve blocks for other indications are mostly supported by retrospective studies and case series. Summary Recent literature strongly supports the use of regional anesthesia for postoperative pain, whereby infusions at peripheral nerves and surgical site are gaining increasing importance. Local anesthetic blocks are valid for the diagnosis of facet joint pain and effective in treating headache. There is a need for further research in diagnostic and therapeutic blocks for chronic pain. Copyright © 2016 YEAR Wolters Kluwer Health, Inc. All rights reserved.