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Rapid sequence induction in obstetrics revisited

Sharp, Lisa Ma; Levy, David Mb

Current Opinion in Anesthesiology: June 2009 - Volume 22 - Issue 3 - p 357–361
doi: 10.1097/ACO.0b013e3283294c4a
Obstetric and gynecological anesthesia: Edited by Marc Van de Velde

Purpose of review The regimen of thiopental, succinylcholine (SCh) and unsupplemented nitrous oxide/oxygen for Caesarean section was first introduced 50 years ago. This review examines which elements have endured, what has changed, and how practice might alter in the very near future.

Recent findings Sugammadex, a cyclodextrin, is capable of rapid reversal of profound rocuronium neuromuscular blockade.

Summary It is now feasible that SCh might be replaced with a high-dose rocuronium–sugammadex combination.

aNottingham and East Midlands School of Anaesthesia, UK

bNottingham University Hospitals NHS Trust, Nottingham, UK

Correspondence to Dr D.M. Levy, Anaesthetics Department, Queen's Medical Centre Campus, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK Fax: +44 115 9783891; e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.