Review ArticleInhalational anaesthesiaBedi, Amit; Howard Fee, J. P. Author Information Department of Anaesthetics and Intensive Care Medicine, The Queen's University of Belfast, Belfast, UK Correspondence to Dr Amit Bedi, MB FRCA, The Department of Anaesthetics and Intensive Care Medicine, 97 Lisburn Road, Belfast, BT9 7BL, UK. Tel: +44 02890 335 785; fax: +44 02890 329 605; e-mail: [email protected]Declaration of interest The authors are entitled to receive royalties from the sale of AmsorbTM. Abbreviations KOH: potassium hydroxide MAC: minimum alveolar concentration NaOH: sodium hydroxide Current Opinion in Anaesthesiology 14(4):p 387-392, August 2001. Buy Abstract Sevoflurane and desflurane have important advantages over isoflurane and halothane. Disadvantages, which the clinician should keep in mind, include the degradation of both agents by soda lime under certain circumstances during closed circuit anaesthesia. As a result compound A and carbon monoxide (CO) may be generated in soda lime canisters and may be inhaled by patients. The extent to which this constitutes a significant problem during routine anaesthesia in humans is not clear. Recent developments in absorbent technology have the potential to reduce any hazard to negligible proportions. Other undesirable properties of the newer inhalation agents include agitation with sevoflurane in children and cardiovascular and airway effects with desflurane. © 2001 Lippincott Williams & Wilkins, Inc.