Review ArticleSide-effects of opioids in chronic pain treatmentLawlor, Peter G.; Bruera, Eduardo Author Information Palliative Care Program, Grey Nuns Community Hospital & Health Centre, Edmonton, AB, Canada Correspondence to Dr Peter Lawlor, Palliative Care Program, Grey Nuns Community Hospital & Health Centre, 1100 Youville Drive West, Room 4324, Edmonton, AB T6L 5X8 Tel: +1 403 450 7730; fax: +1 403 450 7700; e-mail: [email protected] Abbreviations M3G: morphine-3-glucuronide M6G: morphine-6-glucuronide NMDA: N-methyl-D-aspartate Current Opinion in Anaesthesiology 11(5):p 539-545, October 1998. Buy Abstract The emergence of opioid-induced neurotoxicity has gained increasing recognition in the literature in the past decade. Exciting developments at the receptor and intracellular level have revealed some insights into the potential mechanisms underlying this phenomenon. The hitherto reported clinical benefits of opioid rotation and dose reduction in the treatment of opioid toxicity warrant further clarification in prospective studies, particularly in relation to their relative value. © 1998 Lippincott Williams & Wilkins, Inc.