Food allergyComponent-resolved diagnostics in food allergyLidholm, Jonas; Ballmer-Weber, Barbara K; Mari, Adriano; Vieths, Stefan Author Information aPhadia AB, Research & Development Department, Uppsala, Sweden bAllergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, Switzerland cClinical and Experimental Allergy Center for IDI-IRCCS, Rome, Italy dDepartment of Allergology, Paul-Ehrlich-Institut, Langen, Germany Correspondence to Stefan Vieths, Department of Allergology, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, D-63225 Langen, Germany Tel: +49 6103 772400; fax: +49 6103 771258; e-mail: [email protected] Current Opinion in Allergy and Clinical Immunology 6(3):p 234-240, June 2006. | DOI: 10.1097/01.all.0000225166.90768.d6 Buy Metrics Abstract Purpose of review The purpose of this paper is to review and discuss recent studies on component-resolved diagnostics in food allergy, involving panels of pure allergen molecules or arrays of peptides derived from allergen sequences, and to summarize the reporting of new food allergens during the past 2 years. Recent findings Several component-resolved diagnostic studies in food allergy suggest that the use of panels of allergen molecules may allow refined clinical information to be obtained on the likelihood or severity of an allergic food reaction and regarding diagnostic specificity. Further, in some studies the use of pure allergen molecules has led to a clearly higher sensitivity of the immunoglobulin E immunoassay compared with conventional allergen extracts. Summary While common diagnostic methods in allergy assess the presence or absence of allergen-specific sensitization, to date, no in-vitro or in-vivo test exists which exhibits full correlation with clinical food allergy. A multitude of recently reported findings and observations indicate that molecular analysis of allergen sensitization pattern may serve to enhance the clinical utility of immunoglobulin E antibody-based allergy diagnostics. Pure natural and recombinant allergen molecules as well as panels of synthetic peptides have been used for this purpose. Copyright © 2006 Wolters Kluwer Health, Inc. All rights reserved.