MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Enrico HefflerRole of type-2 innate lymphoid cells (ILC2s) in type-2 asthmaVerma, Mukesha; Verma, Divyaa; Alam, Rafeula,bAuthor Information aDivision of Allergy & Immunology, Department of Medicine, National Jewish Health bUniversity of Colorado Denver, School of Medicine, Denver, Colorado, USA Correspondence to Rafeul Alam, MD, PhD, National Jewish Health, Department of Medicine, 1400 Jackson Street, Denver, CO 80206, USA. Tel: +1 303 398 1656; fax: +1 303 270 2180; e-mail: [email protected] Current Opinion in Allergy and Clinical Immunology: February 2022 - Volume 22 - Issue 1 - p 29-35 doi: 10.1097/ACI.0000000000000798 Buy Metrics Abstract Purpose of review The purpose of this review is to provide a synthesis of recent discoveries about type-2 innate lymphoid cells, especially, as they relate to the pathogenesis of asthma. Recent findings We focused on features and characteristics of type-2 innate lymphoid cells (ILC2s) that distinguish them from other type-2 cells, especially Th2 cells. We collected and reviewed data related to human asthma and airway ILC2s. We examined the concept of ILC2 memory and trained immunity. We also analyzed steroid resistance of ILC2s, which is relevant for steroid-resistant asthma. Summary The implications of the findings include an understanding of ILC2 inflammation, and pathways and molecules that can be targeted by biologics and other therapeutic agents for management severe and steroid-resistant asthma Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.