RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. SkonerInnate and adaptive immunity in allergic airway diseaseScadding, Glenis K.a; Scadding, Guy W.b Author Information aRoyal National ENT Hospital, University College Hospitals London. Division of Infection and Immunity, University College London bAllergy and Clinical Immunology, Imperial College, London, UK Correspondence to Glenis K. Scadding, Royal National ENT Hospital, University College Hospitals London. Division of Infection and Immunity, University College London, London, UK. E-mail: [email protected] Current Opinion in Allergy and Clinical Immunology: February 2022 - Volume 22 - Issue 1 - p 10-15 doi: 10.1097/ACI.0000000000000800 Buy Metrics Abstract Purpose of review This article explores recent findings on the involvement of innate immunity in allergic airways disease, concentrating on allergic rhinitis. Recent findings We speculate on the ways in which environmental influences act to initiate inflammation and on how these may have altered in recent decades. Improved understanding of the mechanisms involved may reveal future possibilities for therapy. Summary The complex nature of immunity – both innate and acquired – in airways disease has implications for prevention and for therapy and requires further elucidation. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.