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Natural history of food protein-induced enterocolitis syndrome

Katz, Yitzhak; Goldberg, Michael R.

Current Opinion in Allergy and Clinical Immunology: June 2014 - Volume 14 - Issue 3 - p 229–239
doi: 10.1097/ACI.0000000000000053
FOOD ALLERGY: Edited by Alessandro Fiocchi and Julie Wang

Purpose of review Because of the paucity of reports and variability in the diagnostic criteria utilized, little is known regarding the natural outcome of patients with food protein-induced enterocolitis syndrome (FPIES). Data extracted from referenced manuscripts, as well as allergists’ unpublished observations from across the globe, were used to form a cohesive opinion regarding its natural outcome.

Recent findings All authors concur that there is a generally high rate of recovery for FPIES. The most common foods causing FPIES are milk and soy. Depending upon which study is analyzed, by the age of 3–5 years, approximately 90% of patients recover from their disease. Recovery from FPIES to solid foods, occurs at a later age, but may reflect a later stage of introduction of the food into the diet. An important clinical outcome, although not common, is a shift from FPIES food hypersensitivity to an IgE-mediated food allergy. This necessitates a change in the oral food challenge protocol, if IgE-mediated sensitization is detected.

Summary Over the past several years, there has been an increasing awareness of FPIES. This knowledge should lead to a more timely diagnosis and should reassure parents and practitioners alike regarding its favorable course.

aAllergy and Immunology Institute, Assaf Harofeh Medical Cente

bDepartment of Pediatrics, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Correspondence to Dr Y. Katz, Head, Institute of Allergy and Immunology, Assaf Harofeh Medical Center, Zerifin, 70300, Israel. Tel: +972 8 977 9820; fax: +972 8 924 7124; e-mail:

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