EYE ALLERGY: Edited by Leonard Bielory and Abraham SolomonChemokines in allergic conjunctivitisErdinest, Nira; London, Naomib; Solomon, AbrahamaAuthor Information aDepartment of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel bPrivate Practice, Jerusalem, Israel Correspondence to Abraham Solomon, MD, Cornea & Refractive Surgery Service, Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel. Tel: +972 507874664; e-mail: [email protected] Current Opinion in Allergy and Clinical Immunology: October 2020 - Volume 20 - Issue 5 - p 516-527 doi: 10.1097/ACI.0000000000000676 Buy Metrics Abstract Purpose of review Chemokines are a large group of low molecular weight cytokines that attract and activate leukocytes throughout the body and therefore have a key role in the framework of late-phase allergic responses. The purpose of this article is to provide an overview of the main chemokines involved in allergic conjunctivitis, their primary functions and their physiological roles, and therapies targeted at chemokines and their receptors for ocular allergic diseases. Recent findings In recent years, there have been considerable advances in the understanding of ocular pathophysiology of ocular surface inflammatory diseases including both allergic eye diseases and dry eye syndrome. Several therapies being developed for dry eye inflammation are recognized as possible therapies for ocular allergic diseases as there are often common chemokines involved in both disease spectra. Summary Chemokines represent an integral part of the late-phase cascade of ocular allergic inflammation. A deep understanding of specific chemokines and their interactions will help in targeting therapies to effectively manage ocular clinical findings and symptoms of allergic eye disease. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.