RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. SkonerDendritic cell subset expression in severe chronic rhinosinusitis with nasal polypsPerez-Novo, Claudinaa; Pezato, Rogériob Author Information aDepartment Biomedical Sciences, University Antwerp; Laboratory of Proteinchemistry, Proteomics Epigenetic Signaling, Wilrijk, Belgium bDepartment of Otolaryngology, Head and Neck Surgery, ENT Research Laboratory, Federal University of São Paulo, São Paulo, Brazil Correspondence to Rogério Pezato, Department of Otolaryngology, Head and Neck Surgery, ENT Research Laboratory, Federal University of São Paulo, Rua dos Otonis, 700 Piso Superior, Vila Clementino, 04025-002 São Paulo, SP, Brazil. Tel: +11 5579 6018; fax: +11 5579 6018; e-mail: [email protected] Current Opinion in Allergy and Clinical Immunology: February 2017 - Volume 17 - Issue 1 - p 1-4 doi: 10.1097/ACI.0000000000000328 Buy Metrics Abstract Purpose of review Two main pillars are implicated in nasal polyposis development: a severe imbalance in immunomodulation and a mechanical dysfunction because of an abnormal remodeling process. Dendritic cells play a crucial role in the link between innate and adaptive immune response and orchestrating the T-cell response and are implicated in the severe inflammatory process found in nasal polypoid tissue. This review summarizes the existent knowledge about dendritic cells in nasal polyposis. Recent findings Dendritic cells are found increased in nasal polyposis, regardless of subset. Of interest, plasmacytoid dendritic cells are decreased in patients with a more severe Th2 profile, suggesting an important role of the cytokines milieu in their functional response or that plasmacytoid dendritic cell could act mitigating the inflamed process found in polypoid tissue. Summary Understanding the dendritic cell subset expression in different environments, as well as the effect of these subsets on T-cell differentiation will greatly improve the development of new therapies in nasal polyposis. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.