IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert BushAllergen immunotherapy for the polyallergic patientWahn, Ulrich Author Information Department of Ped Pneumology and Immunology, Charité, Berlin, Germany Correspondence to Prof Ulrich Wahn, Department of Ped Pneumology and Immunology, Charité, Augustenburger Platz 1, D-13353 Berlin, Germany. Tel: +0049 30450559498; e-mail: [email protected] Current Opinion in Allergy and Clinical Immunology: December 2016 - Volume 16 - Issue 6 - p 571-575 doi: 10.1097/ACI.0000000000000321 Buy Metrics Abstract Purpose of review Currently, dramatic changes in allergy treatment can be observed in many countries: The availability of monocomponent products with pharmaceutical quality for sublingual immunotherapy is likely to have a strong impact on all immunotherapy practices and the specialty in general. The market for patient-named products with allergenic mixtures can be expected to shrink. Allergists are concerned about the possibility that single-source products for immunotherapy might be insufficient to serve the needs of all ‘polyallergic’ patients. Recent findings The availability of molecular IgE-testing as a novel diagnostic tool will clarify that much of the previously perceived ‘polyallergy’ has to be interpreted as ‘pseudo-polyallergy.’ It can be predicted that the needs of the vast majority of polysensitizations will be met by the novel allergen components, which are marketing for subcutaneous immunotherapy and sublingual immunotherapy. In countries where compounding of ‘patient-tailored allergen extracts’ has been traditionally practiced, diagnostic and therapeutic procedures are currently being challenged. A recent survey (Allermix) in Europe suggests that allergists believe that the vast majority of polyallergic patients can be adequately treated with registered products without compounding. Compounding by allergists or allergen manufacturers will still be necessary for a limited number of patients with several independent allergies. Summary It appears that a limited portfolio aligned to health authority recommendations will be sufficient to answer treatment habits of allergists even in polysensitized patients. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.