OCCUPATIONAL DISEASE: Edited by Susan M. Tarlo and Piero MaestrelliFarm animal models of organic dust exposure and toxicity insights and implications for respiratory healthMcClendon, Chakia J.; Gerald, Carresse L.; Waterman, Jenora T. Author Information aDepartment of Animal Sciences bDepartment of Energy and Environmental Systems, North Carolina Agricultural and Technical State University, Greensboro, North Carolina cPulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA Correspondence to Jenora T. Waterman, PhD, Department of Animal Sciences, School of Agriculture and Environmental Sciences, North Carolina Agricultural and Technical State University, 1601 East Market Street, Greensboro, NC 27411, USA. Tel: +1 336 285 4815; fax: +1 336 334 7288; e-mail: [email protected] Current Opinion in Allergy and Clinical Immunology: April 2015 - Volume 15 - Issue 2 - p 137-144 doi: 10.1097/ACI.0000000000000143 Buy Metrics Abstract Purpose of review Modern food animal production is a major contributor to the global economy, owing to advanced intensive indoor production facilities aimed at increasing market readiness and profit. Consequences of these advances are accumulation of dusts, gases, and microbial products that diminish air quality within production facilities. Chronic inhalation exposure contributes to onset and exacerbation of respiratory symptoms and diseases in animals and workers. This article reviews literature regarding constituents of farm animal production facility dusts, animal responses to production building and organic dust exposure, and the effect of chronic inhalation exposure on pulmonary oxidative stress and inflammation. Recent findings Porcine models of production facility and organic dust exposures reveal striking similarities to observations of human cells, tissues, and clinical data. Oxidative stress plays a key role in mediating respiratory diseases in animals and humans, and enhancement of antioxidant levels through nutritional supplements can improve respiratory health. Summary Pigs are well adapted to the exposures common to swine production buildings and thus serve as excellent models for facility workers. Insight for understanding mechanisms governing organic dust associated respiratory diseases may come from parallel comparisons between farmers and the animals they raise. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.