MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by Jean Bousquet and J. Andrew GrantTaste receptors in asthmaGrassin-Delyle, Stanislas; Naline, Emmanuel; Devillier, Philippe Author Information aLaboratoire de Pharmacologie Respiratoire UPRES EA220, Hôpital Foch, Suresnes bUniversité Versailles Saint-Quentin, UFR Sciences de la Santé Simone Veil, Montigny-Le-Bretonneux, France Correspondence to Stanislas Grassin-Delyle, Laboratoire de Pharmacologie Respiratoire, UPRES EA220, Hôpital Foch, 11 rue Guillaume Lenoir, F-92150 Suresnes, France. Tel: +33 146 252 791; fax: +33 140 999 657; e-mail: [email protected] Current Opinion in Allergy and Clinical Immunology: February 2015 - Volume 15 - Issue 1 - p 63-69 doi: 10.1097/ACI.0000000000000137 Buy Metrics Abstract Purpose of review Although today's cornerstone therapies for asthma (inhaled bronchodilators and corticosteroids) target airway narrowing and lung inflammation, about half of treated asthmatic patients do not achieve good disease control. There is a clear need for new therapeutic approaches and novel drug targets. Recent research has unexpectedly revealed that certain taste receptors (particularly those involved in bitter taste transduction) are expressed in lung tissue. Recent findings Bitter taste receptors are expressed in several cell types in the lungs (such as chemosensory cells, epithelial cells, smooth muscle cells, lymphocytes, and macrophages) and variously involved in ciliary beating, muscle relaxation, and/or inhibition of the production of inflammatory mediators. Here, we review recent research on the role of bitter taste receptors in experimental models of asthma and in asthmatics. Summary The currently available data suggest that bitter taste receptor agonists have therapeutic potential in chronic obstructive airway diseases such as asthma. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.