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Anaphylaxis: still a ghost behind allergen immunotherapy

Makatsori, Melina; Calderon, Moises A.

Current Opinion in Allergy and Clinical Immunology: August 2014 - Volume 14 - Issue 4 - p 316–322
doi: 10.1097/ACI.0000000000000075
ANAPHYLAXIS AND INSECT ALLERGY: Edited by Jeffrey G. Demain and Gianenrico Senna

Purpose of review Allergen immunotherapy has been shown to be an effective treatment for respiratory allergies and Hymenoptera venom allergy. However, concern regarding its potential to cause anaphylaxis may limit its use. This review aims to assess whether anaphylaxis is still a worry when administering subcutaneous (SCIT) and sublingual immunotherapy (SLIT).

Recent findings Retrospective surveillance surveys and one ongoing North American prospective study have helped to characterize the incidence and risk factors for fatal and nonfatal systemic reactions to SCIT. The latest rate of very severe, World Allergy Organization grade 4, systemic reactions was similar to the previously reported rates of near-fatal reactions, that is, 1 in 1 million injections. Regarding SLIT, no fatalities have been reported. Case reports of anaphylaxis in clinical practice and in some clinical trials have been described; however, given the number of doses administered daily throughout the world, the number is very small.

Summary Identification of possible risk factors and the introduction of safety guidelines and practice parameters have enabled the reduction in immunotherapy related systemic reactions. However, it is important that clinicians remain vigilant when administering immunotherapy and should be prepared to provide emergency treatment if required.

aSection of Allergy and Clinical Immunology, Imperial College London

bNational Heart and Lung Institute, Royal Brompton Hospital, London, UK

Correspondence to Moises A. Calderon, Professor, Section of Allergy and Clinical Immunology, Imperial College London, London, SW3 6LY, UK. Tel: +44 207 351 8024; e-mail:

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