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Innate lymphoid cells in asthma: when innate immunity comes in a Th2 flavor

Vercelli, Donata; Gozdz, Justyna; von Mutius, Erika

Current Opinion in Allergy and Clinical Immunology: February 2014 - Volume 14 - Issue 1 - p 29–34
doi: 10.1097/ACI.0000000000000023
MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by Jean Bousquet and J. Andrew Grant

Purpose of review Asthma is typically considered as an immunologic Th2 cell-mediated disease, a notion that is still inspiring many therapeutic strategies. In the past years, however, an innate immune cell type has been discovered in mice that resides in the mucosa and secretes the Th2 cytokines IL-13 and IL-5 in response to IL-33 and IL-25 released by a damaged epithelium. These cells [now named group 2 innate lymphoid cells (ILC2s)] are rare, systemically dispersed, long-lived, and exist in humans. Recent work shows that ILC2s are critical for the development of asthma and related phenotypes in mice. Their role in human asthma remains unknown.

Recent findings This article reviews the most recent work that highlights ILC2s and the mechanisms underlying their critical role in experimental asthma. We also review the results of asthma therapeutic trials that targeted IL-13 and IL-5, the products of both Th2 cells and ILC2s.

Summary Although the limited success of these trials is often quoted to dismiss the role of Th2 immunity as a whole, we propose that Th2 cytokines released by ILC2s may be critical for human asthma, but are not adequately neutralized because they are not readily accessible in peripheral tissues.

aFunctional Genomics Laboratory, Arizona Respiratory Center

bDepartment of Cellular and Molecular Medicine

cThe BIO5 Institute, University of Arizona, Tucson, Arizona, USA

dDr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany

Correspondence to Donata Vercelli, MD, The BIO5 Institute, Rm. 339, 1657 E. Helen Street, Tucson, AZ 85719, USA. Tel: +1 520 626 2567; fax: +1 520 626 6623; e-mail:

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