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Component-resolved diagnosis in pediatric allergic rhinoconjunctivitis and asthma

Melioli, Giovanni; Passalacqua, Giovanni; Canonica, Giorgio Walter; Baena-Cagnani, Carlos E.; Matricardi, Paolo

Current Opinion in Allergy and Clinical Immunology: August 2013 - Volume 13 - Issue 4 - p 446–451
doi: 10.1097/ACI.0b013e32836274d8

Purpose of review The aim of this review is to update readers on the growing impact of a molecular approach (CRD) to the diagnosis and treatment of children with respiratory allergies

Recent findings A large panel of highly purified natural or recombinant species-specific and cross-reacting allergenic molecules is now available for clinical purposes. Species-specific molecules allow identifying specific sensitization toward a given allergenic source. Cross-reacting molecules allow interpreting polysensitization patterns that cannot be detailed using routine skin prick tests or specific IgE tests based on allergenic extracts. These molecular tools are transforming and improving the interpretation of clinical and laboratory tests used to define patients’ IgE-sensitization profile.

Summary The accurate dissection of the IgE repertoire offers new possibilities in the diagnosis, prophylaxis and treatment of pediatric allergic rhinoconjunctivitis and asthma.

aDepartment of Experimental Medicine, Istituto Giannina Gaslini, Genova

bDepartment of Internal Medicine, Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy

cResearch Centre in Respiratory Medicine, Catholic University, Cordoba, Argentina

dDepartment of Pediatric Pneumology and Immunology, Charité University Medical Centre, Berlin, Germany

Correspondence to Giovanni Melioli, MD, Department of Experimental Medicine, Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, Genova 16147, Italy. Tel: +39 010 563 6557; fax: +39 010 399 4168; e-mail:

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