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Molecular immunology of allergic conjunctivitis

Irkec, Murat T.; Bozkurt, Banu

Current Opinion in Allergy and Clinical Immunology: October 2012 - Volume 12 - Issue 5 - p 534–539
doi: 10.1097/ACI.0b013e328357a21b
EYE ALLERGY: Edited by Leonard Bielory and Stefano Bonini

Purpose of review Successful treatment of allergic eye disease depends on understanding the pathophysiology of ocular allergy. Thus, in this review, recent experimental and clinical research that has provided significant information about the immunopathology of allergic eye disease will be discussed.

Recent findings Recently, role of various cells, cytokines and chemokines has been scrutinized in the immunopathogenesis of ocular allergy. In this respect, current research highlights contribution of special molecules and cells in the development and clinical features of immunoglobulin E (IgE) and T-cell-mediated eye allergies.

Summary Recent findings in molecular immunology of ocular allergy, which comprise complex inflammatory conditions of the conjunctiva, have enabled us to better understand the pathophysiology of these diseases and have aided in the potential development of new therapeutic agents.

aHacettepe University, Faculty of Medicine, Department of Ophthalmology, Ankara

bSelcuk University, Selcuklu Medical Faculty, Department of Ophthalmology, Konya, Turkey

Correspondence to Professor Murat T. Irkec, Hacettepe University, Faculty of Medicine, Department of Ophthalmology, Cornea and Ocular Surface Diseases Unit, Sıhhiye, 06100 Ankara, Turkey. Tel: +90 312 305 17 77; fax: +90 312 425 42 44; e-mail:

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