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Corneal angiogenesis and lymphangiogenesis

Regenfu, Birgit; Bock, Felix; Cursiefen, Claus

Current Opinion in Allergy and Clinical Immunology: October 2012 - Volume 12 - Issue 5 - p 548–554
doi: 10.1097/ACI.0b013e328357b4a2
EYE ALLERGY: Edited by Leonard Bielory and Stefano Bonini

Purpose of review The purpose of the present review is to describe new antilymphangiogenic treatment strategies and recent findings on strain-dependency of corneal lymphangiogenesis and the interdependency between blood and lymphatic vessel growth.

Recent findings Studies on mice have revealed that apart from haemangiogenesis, lymphangiogenesis can also differ markedly between several mouse strains under normal and inflammatory conditions. Although haemangiogenesis and lymphangiogenesis are closely interconnected in their spatial-temporal patterning, recent data suggest that they can also occur independently.

Summary Understanding the coordinated regulation of blood and lymphatic vessel growth and genetic factors determining lymphangiogenesis in more detail could improve the development of specifically targeted antihaemangiogenic or antilymphangiogenic strategies.

Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany

Correspondence to Professor Dr med. Claus Cursiefen, Kerpenerstr. 62, 50924 Köln, Germany. Tel: +49 221 4784300; e-mail:

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.