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Vitamin D and chronic rhinitis

Abuzeid, Waleed M.; Akbar, Nadeem A.; Zacharek, Mark A.

Current Opinion in Allergy and Clinical Immunology: February 2012 - Volume 12 - Issue 1 - p 13–17
doi: 10.1097/ACI.0b013e32834eccdb
RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner

Purpose of review To discuss the role of vitamin D in chronic rhinitis and chronic rhinosinusitis (CRS).

Recent findings Vitamin D has been shown to have an immunomodulatory effect with a significant impact on immune function. Specifically, vitamin D regulates the mechanisms which suppress the inflammatory response and direct the differentiation fate of immune cells. Vitamin D has been shown to play an important role in asthma, and the concept of the unified airway model allows the extrapolation of vitamin D as a critical player in chronic rhinitis and rhinosinusitis.

Summary Recent findings on the function of vitamin D may explain aspects of the pathophysiology of chronic rhinitis and CRS, and may help direct future treatment of these diseases.

Department of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA

Correspondence to Mark A. Zacharek, MD, FACS, FAAOA, Clinical Associate Professor of Otorhinolaryngology, Department of Otolaryngology/Head and Neck Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. Tel: +1 734 232 0120; fax: +1 734 936 9625; e-mail:

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