Vitamin D and chronic rhinitisAbuzeid, Waleed M.; Akbar, Nadeem A.; Zacharek, Mark A.Current Opinion in Allergy and Clinical Immunology: February 2012 - Volume 12 - Issue 1 - p 13–17 doi: 10.1097/ACI.0b013e32834eccdb RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner Abstract Author Information Purpose of review To discuss the role of vitamin D in chronic rhinitis and chronic rhinosinusitis (CRS). Recent findings Vitamin D has been shown to have an immunomodulatory effect with a significant impact on immune function. Specifically, vitamin D regulates the mechanisms which suppress the inflammatory response and direct the differentiation fate of immune cells. Vitamin D has been shown to play an important role in asthma, and the concept of the unified airway model allows the extrapolation of vitamin D as a critical player in chronic rhinitis and rhinosinusitis. Summary Recent findings on the function of vitamin D may explain aspects of the pathophysiology of chronic rhinitis and CRS, and may help direct future treatment of these diseases. Department of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA Correspondence to Mark A. Zacharek, MD, FACS, FAAOA, Clinical Associate Professor of Otorhinolaryngology, Department of Otolaryngology/Head and Neck Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. Tel: +1 734 232 0120; fax: +1 734 936 9625; e-mail: firstname.lastname@example.org Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.