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Tissue remodeling in chronic rhinosinusitis

Van Bruaene, Nicholas; Bachert, Claus

Current Opinion in Allergy and Clinical Immunology: February 2011 - Volume 11 - Issue 1 - p 8–11
doi: 10.1097/ACI.0b013e32834233ef
Rhinitis, sinusitis and upper airway disease: Edited by Ruby Pawankar and David P. Skoner

Purpose of review To summarize the current knowledge on remodeling in chronic sinus disease.

Recent findings Chronic sinus disease is characterized by persistent inflammation of the nasal and paranasal mucosa and is currently classified into two major subgroups on the basis of the absence (CRSsNP) or presence (CRSwNP) of nasal polyps. Transforming growth factor-beta and matrix metalloproteinases are critical factors involved in the remodeling process.

Summary Remodeling is clearly present in chronic sinus disease. Transforming growth factor-beta has been implicated as an important factor in remodeling processes involved in chronic sinus disease, and serves as a main switch for different remodeling patterns in chronic sinus disease.

Upper Airways Research Laboratory, Department of Oto-Rhino-Laryngology, Ghent University, Belgium

Correspondence to Nicholas Van Bruaene, MD, Department of Oto-Rhino-Laryngology, Ghent University Hospital, Ghent University, B-9000 Ghent, Belgium Tel: +32 9332 6927; fax: +32 9332 4993; e-mail:

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