Drug allergy: Edited by Bernard Thong and Miguel BlancaSelective immediate hypersensitivity reactions to NSAIDsCanto, Maria Gabriela; Andreu, Isabel; Fernandez, Javier; Blanca, Miguel Author Information aServicio de Alergologia, Hospital Infantal Leonor, Madrid, Spain bInstituto de Tecnologia Química, UPV-CSIC, Valencia, Spain cServicio de Alergologia, Hospital Carlos Haya, Málaga, Spain dElche Hospital, Alicante, Spain Correspondence to Gabriela Canto Diez, Hospital Infanta Leonor, Gran via del Este No. 80, 28031 Madrid, Spain Tel: +34 619242278; fax: +34 911919092; e-mail: [email protected] Current Opinion in Allergy and Clinical Immunology 9(4):p 293-297, August 2009. | DOI: 10.1097/ACI.0b013e32832db943 Buy Metrics Abstract Purpose of review Selective immediate reactions to NSAIDs imply that patients develop a urticarial/anaphylactic response to a single drug with good tolerance to other compounds. No systematic review of these reactions has yet been made. Recent findings With the increase in consumption of NSAIDs, these have become one of the most common drugs inducing hypersensitivity reactions. Although cross-intolerance reactions are the most common, a significant proportion is selective responses. As specific IgE antibodies are not always found, there is only indirect evidence supporting an IgE-mediated mechanism in selective NSAID reactors. Summary Selective immediate reactions to NSAIDs must be considered when a patient develops urticaria or anaphylaxis after intake of one drug with good tolerance to drugs from other groups or even a drug from the same group with a slightly different chemical structure. Further research is required to identify the antigenic determinant structures recognized. Copyright © 2009 Wolters Kluwer Health, Inc. All rights reserved.