Asthma remains a severe health problem since current therapies are directed to suppressing, rather than preventing or reversing, the primary disease process. Clearly, a greater understanding of the pathogenesis of asthma is critical to the development of better therapeutic modalities. In this review, we discuss the recent advancements in research targeting the role of airway remodeling in asthma.
Epithelial fragility and abnormalities are being recognized as important facets of asthma, as are other features of remodeling such as angiogenesis, goblet cell hyperplasia and thickened lamina reticularis. Significantly, these anomalies occur early in disease pathogenesis. However, their impact on disease severity remains unclear.
Although an altered immune response is undoubtedly important to the pathogenesis of asthma, there is increasing evidence that the tissue-specific manifestations occur independently of inflammation and significantly impact on disease development and severity.
aJames Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Faculty of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, Canada
bDepartment of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
Correspondence to Darryl A. Knight, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Rm 166, St Paul's Hospital, 1081 Burrard Street, Vancouver, Canada, V6Z 1Y6 Tel: +1 604 6822344; e-mail: firstname.lastname@example.org