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Pediatric health-related quality of life questionnaires in clinical trials

Raat, Hein; Mohangoo, Ashna D; Grootenhuis, Martha A

Current Opinion in Allergy and Clinical Immunology: June 2006 - Volume 6 - Issue 3 - p 180–185
doi: 10.1097/01.all.0000225157.67897.c2
Outcome measures

Purpose of review This review summarizes recent studies on the feasibility, reliability and validity of pediatric health-related quality of life questionnaires and gives an overview of recent applications of these measures in pediatrics.

Recent findings The often-applied short form of the Child Health Questionnaire (CHQ-PF28) provides reliable physical and psychosocial summary measures, but reliable estimates for each scale require the longer version (CHQ-PF50). In addition to this questionnaire, the Pediatric Quality of Life Inventory is another reliable and valid measure. The TNO-AZL Preschool Children Quality of Life questionnaire is a feasible and reliable measure for preschool children. Generally, generic questionnaires are less sensitive to the impact of specific diseases than are disease-specific questionnaires. Parent and self-reports provide different outlooks on quality of life, which complement each other.

Summary There are several feasible, reliable and validated pediatric quality of life questionnaires that can be used in clinical trials. These include generic and disease-specific questionnaires and health profile measures, as well as preference-based measures in pediatric settings. Generally, a combination of these types of questionnaires would be the most appropriate approach. Moreover, a combination of parent and self-reports should be applied. Appropriate selection of outcome measures will enhance the quality of pediatric studies and the ability to assess treatment effects in clinical trials.

aDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands

bPaediatric Psychosocial Department, Academic Medical Center, Amsterdam, The Netherlands

Correspondence to Hein Raat, Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands Tel: +31 10 463 8460; fax: +31 10 463 8475; e-mail:

Copyright © 2006 Wolters Kluwer Health, Inc. All rights reserved.