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Cerebral Small Vessel Disease

  • Creator:   Chinese Medical Journal
  • Updated:   4/6/2021
  • Contains:  9 items
Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies. Increasing small vessel disease burden is associated with risk of incident stroke and dementia, as well as other neuropsychiatric symptoms. Cerebral small vessel disease is common in aging adults and represents a major risk factor for multiple acute and chronic neurologic diseases. Increased awareness of cerebral small vessel disease as a modifiable risk factor holds potential for reducing neurologic disease morbidity and mortality across diverse populations worldwide.

Pandemic of the aging society — sporadic cerebral small vessel disease

Lau, Alexander Yuk Lun; Ip, Bonaventure Yiu Ming; Ko, Ho; More

Chinese Medical Journal. 134(2):143-150, January 20, 2021.

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Highlight: This review provides an update on the pathophysiology, risk factors, biomarkers, and the determinants and spectrum of the clinical manifestation of sporadic CSVD.

HTRA1-related autosomal dominant cerebral small vessel disease

Liu, Jing-Yi; Zhu, Yi-Cheng; Zhou, Li-Xin; More

Chinese Medical Journal. 134(2):178-184, January 20, 2021.

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Highlight: HTRA1-related autosomal dominant CSVD is present as a mild phenotype of CARASIL. The trend of regional concentration of mutation sites may be related to the concentration of key sites in these regions which are responsible for pathogenesis of HTRA1-related autosomal dominant CSVD.

Magnetic resonance imaging manifestations of cerebral small vessel disease: automated quantification and clinical application

Zhao, Lei; Lee, Allan; Fan, Yu-Hua; More

Chinese Medical Journal. 134(2):151-160, January 20, 2021.

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Highlight: This review explores the recent progress in CSVD neuroimaging feature quantification and provides an overview of the clinical consequences of these CSVD features as well as the possibilities of using these features as endpoints in clinical trials. 

Relationship between serum homocysteine levels and long-term outcomes in patients with ST-segment elevation myocardial infarction

Si, Jin; Li, Xue-Wen; Wang, Yang; More

Chinese Medical Journal. 132(9):1028-1036, May 5, 2019.

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Highlight: This study evaluated the predictive value of serum homocysteine (HCY) levels on prognosis in patients with ST-segment elevation myocardial infarction (STEMI).

Trans-cranial Doppler predicts early neurologic deterioration in anterior circulation ischemic stroke after successful endovascular treatment

He, Yan-Bo; Su, Ying-Ying; Rajah, Gary B.; More

Chinese Medical Journal. 133(14):1655-1661, July 20, 2020.

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Highlight: Trans-cranial Doppler (TCD) examination of EVT patients may be used as a real-time tool to detect END predictors, such as the higher PI and iMFV/MBP, allowing for better post-thrombectomy management in anterior circulation ischemic stroke (ACIS) patients.

Assessing the association of appropriateness of coronary revascularization and 1-year clinical outcomes for patients with stable coronary artery disease in China

Lin, Shen; Zhang, Heng; Rao, Chen-Fei; More

Chinese Medical Journal. 133(1):1-8, January 5, 2020.

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Highlight: In patients with appropriate indications according to Chinese appropriate use criteria (AUC), coronary revascularization was associated with significantly lower risk of MACCEs at 1 year. No benefit was found in coronary revascularization in patients with inappropriate indications.

Predicting asymptomatic coronary artery stenosis by aortic arch plaque in acute ischemic cerebrovascular disease: beyond the cervicocephalic atherosclerosis?

Ma, Xin; Kong, Qi; Wang, Chen; More

Chinese Medical Journal. 132(8):905-913, April 20, 2019.

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Highlight: Thicker, severe-extent, and complex aortic arch plaque (AAP) were significant markers of the concomitant ACAS ≥50% in acute ischemic cerebrovascular disease (AICVD), possibly superior to the indicative value of cervical and intracranial atherosclerotic stenosis.